鍚嶈瘝瑙ｉ噴锛?/p>
1
銆侀鍏虫秷闄わ紙
first pass elimination
锛?/p>
/
棣栧叧浠ｈ阿锛?/p>
first pass metabolism
锛?/p>
/
棣栧叧鏁?/p>
搴旓紙
first pass effect
锛夛細浠庤儍鑲犻亾鍚告敹鍏ラ棬闈欒剦绯荤粺鐨勮嵂鐗╁湪鍒拌揪鍏ㄨ韩琛�娑插惊鐜墠蹇呭厛閫?/p>
杩囪倽鑴忥紝濡傛灉鑲濊剰瀵瑰叾浠ｈ阿鑳藉姏寰堝己锛屾垨鐢辫儐姹佹帓娉勭殑閲忓ぇ锛屽垯杩涘叆鍏ㄨ韩琛�娑插惊鐜唴鐨勬湁
鏁堣嵂鐗╅噺鏄庢樉鍑忓皯锛岃繖绉嶄綔鐢ㄧО涓洪鍏虫秷闄ゃ�?/p>
2
銆佹帓娉勶紙
excretion
锛?/p>
:
鎺掓硠鏄嵂鐗╀互鍘熷舰鎴栦唬璋骇鐗╃殑褰㈠紡缁忎笉鍚岄�斿緞鎺掑嚭浣撳鐨勮繃
绋嬶紝鏄嵂鐗╀綋鍐呮秷闄ょ殑閲嶈缁勬垚閮ㄥ垎銆?/p>
3
銆佽偁鑲濆惊鐜紙
enterohepatic cycle
锛?/p>
:
閮ㄥ垎鑽墿缁忚倽鑴忚浆鍖栧舰鎴愭瀬鎬ц緝寮虹殑姘存憾鎬т唬
璋骇鐗╋紝琚垎娉屽埌鑳嗘眮鍐呯粡鐢辫儐閬撳強鑳嗘�荤杩涘叆鑲犺厰锛岀劧鍚庨殢绮究鎺掓硠锛岀粡鑳嗘眮鎺掑叆鑲犺厰
鐨勮嵂鐗╅儴鍒嗗彲鍐嶇粡灏忚偁涓婄毊缁嗚優鍚告敹缁忚倽鑴忚繘鍏ヨ娑插惊鐜紝杩欑鑲濊剰銆佽儐姹併�佸皬鑲犻棿鐨勫惊
鐜О鑲犺倽寰幆銆?/p>
4
銆佸崐琛版湡锛?/p>
half life
锛夛細琛�娴嗚嵂鐗╂祿搴︿笅闄嶄竴鍗婃墍闇�瑕佺殑鏃堕棿銆傚叾闀跨煭鍙互鍙嶆槧浣撳唴
鑽墿娑堥櫎閫熷害銆?/p>
5
銆佹竻闄ょ巼锛?/p>
clearance
锛?/p>
CL
锛夛細鏈轰綋娑堥櫎鍣ㄥ畼鍦ㄥ崟浣嶆椂闂村唴娓呴櫎鑽墿鐨勮娴嗗绉紝涔?/p>
灏辨槸鍗曚綅鏃堕棿鍐呮湁澶氬皯浣撶Н琛�娴嗕腑鎵�鍚嵂鐗╄鏈轰綋娓呴櫎锛屾槸浣撳唴鑲濊剰銆佽偩鑴忓拰鍏朵粬鎵�鏈夋秷
闄ゅ櫒瀹樻竻闄よ嵂鐗╃殑鎬诲拰銆?/p>
6
銆佽〃瑙傚垎甯冨绉紙
apparent volume of distribution,
d
V
锛?/p>
:
鎸囧綋琛�娴嗗拰缁勭粐鍐呰嵂鐗╁垎
甯冭揪鍒板钩琛℃椂锛屼綋鍐呰嵂鐗╂寜琛�娴嗚嵂鐗╂祿搴﹀湪浣撳唴鍒嗗竷鎵�闇�浣撴恫瀹圭Н銆?/p>